Abstract: Nursing is a professional practice. Evidence-based practice is important in improving the quality of nursing care. Lack of research knowledge and less involvement in research are the main barriers to evidence-based practice in improving nursing clinical practice. The study aimed to assess the opinions and practice on research among nurses in the selected hospital in Batticaloa district, Sri Lanka. A sample of 270 nurses was selected using a systematic sampling technique. A self-administered questionnaire assessed the socio-demographic characters, nurses’ opinions towards research, and practices on research.