Abstract: COVID-19 spread in Kenya has been growing at a very high rate in the recent past. According to the Kenya’s ministry of health, the confirmed COVID-19 infections as of 19th July 2020 was 13,353 with recorded 5,122 recoveries and 234 deaths. Based on quarantine data, there is media speculation about COVID-19 manifesting gender dimension, however, no studies have been carried out to establish the gender-based dimension in the community. This paper aimed at: formulating gender based Mathematical model, estimate gender-based disease burden in the community using quarantine data and using estimated parameters and states to predict dynamics of the disease in the quarantine centers.