Abstract: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, covers 80% of all thyroid cancers and often occurs in women than in men, the frequency of women is 3 times higher than in men. Several studies have shown that estrogen and its receptors are involved in the development of various types of malignant tumors including breast cancer, prostate cancer, ovarian cancer, endometrial cancer, colon cancer, lung cancer and thyroid cancer. Estrogen Receptor (ER) has been shown to increase PTC cell proliferation and cell line growth. Objective: To assess ERα immunohistochemistry expression in Papillary thyroid carcinoma.