Abstract: The objective of this study is to determine the antimicrobial properties of medicinal plants like Mentha selvestis, Osimum basillus, Rosa indica, Rosa sinensis, Punica granatum. The aquaeous extracts was obtained by distillation method by liebig,s condenser. It was applied on skin patients who had Acne, dryness, pimples with pus, Malassezia furfur, fusarium proliferatum. It was found that Mentha piperita was most effective for Malassezia furfur. For fusarium proliferatum it was found that basil showed best result as compared to DMSO. It was found that for Malassezia furfur DMSO showed zone of inhibition 16mm as compared to mentha piperita which had 25mm. In agar plate of fusarium proliferatum DMSO inhibited 0.6mm area as compared to Osimum basilicum which had 25mm.