Abstract: Pressure injury (PI) is such a common complications that impair quality of life and become the source of sufferings for the patients and care-givers in spinal cord injury (SCI) patients. Management of PI in SCI population is also expensive specially in developing nations. Autologous Platelet-Rich Fibrin (PRF) is simpler, cost-effective, safe new approach towards pressure injury managements. As second-generation Platelet Rich Plasma (PRP), PRF contains more growth factors than PRP. There are no studies on PRF membrane use in PI management in SCI population. Following PRF use there was improved granulation tissue formation in this patient. Here for the first time PRF membrane use in PI management in SCI population has been reported in this case.