Abstract: Princely State of Mysore in India was under the British colonial rule during 1881 to 1947.This research article aims to document the role of Princely Mysore State in campaigning against the outbreak of plague. The methodology adopted is the historical perspective. Modus operandi adopted by the Princely Mysore state to counter the deadly epidemic is also highlighted. Plague bacillus took away the lives of over 20 million people in India during 1896-1918, merciless in its ravages and sweeping off thousands in a day. The plague outbreak reigned for two decades and took toll of a crore people in the Princely State of Mysore. Lack of medical facilities had brought very high mortality.