Abstract: Colorectal cancer (CRC) is the third most common cancer type in humans, the fourth most common cause of death annually. Survivin (known as SVV and BIRC5) is the smallest member of the inhibitor of apoptosis protein (IAP) family and it correlates with not only inhibition of apoptosis and a decreased rate of cell death, but also resistance to chemotherapy and tumor aggressiveness.The main goal of this study was to evaluate gene expression of survivin by RT-PCR as well as estimate the level of Oncostatin-M and antioxidants in the peripheral blood of patients with colorectal carcinoma and its relation to metastasis. Results: Our study shows high expression of survivin (p <0.001) and Oncostatin-M (p <0.001) in patients with colorectal cancer more than healthy persons. The present study revealed that CEA concentration was increased in colorectal carcinoma patients group compared to control group, p value was 0.010. Additionally, this study shows high elevation of antioxidants as catalase (p <0.001) , malondialdehyde (p <0.001) in patients group than control group. This proves that early detection of survivin and Oncostatin-M has important role in early screening of colorectal cancer.