Abstract: This study was designed to investigate the effect of moderate intensity exercise on lipoprotein- lipid profile of Haramaya University community. Both male and female individuals were involved in the study and the study lasted twelve consecutive weeks. Individuals used for the study were Haramaya University community aged eighteen up to thirty years old and free from any impairment or chronic diseases. Purposive sampling technique was used to select the study participants. Twenty individuals, men (n = 10) and women (n = 10) were recruited for the study. All completed the study period properly. Laboratory measurements were conducted at Haramaya University higher health centre.