Abstract: Traumatic brain injury (TBI) is a significant health concern, with mild to moderate cases comprising most occurrences. Early detection of intracranial hemorrhage is critical for preventing complications. While CT scans are widely used, many are unnecessary. S100B, a biomarker linked to blood-brain barrier disruption, has shown potential for TBI assessment. While serum S100B is well studied, its presence in saliva remains underexplored as a diagnostic tool.