IJSRP, Volume 6, Issue 3, March 2016 Edition [ISSN 2250-3153]
Shakeel Ahmad Khan, Sammia Shahid, Zulfiqar Ali Khan, Ahsan Iqbal
Peucedanum graveolens has been perceived as a wellspring of common cell reinforcement’s aginst oxidative mechanism. The purposes of that study were to assess the antioxidative potential of different extracts of P. graveolens roots in different solvent systems by computing yield, TPC, TFC, DPPH and linoleic acid per-oxidation. Extracts yield observed in this study are found in range 6.90-10.80%.Total phenolic contents (TPC) and total flavonoid contents (TFC) were observed in the scale of 0.90-2.49 mg and 3.20-5.70 mg respectively. The DPPH-IC50 and %age-inhibition per-oxidation examined by different extracts of P. graveolens roots were come in the extent of 23.9-80.9 µg/mL and 40-71.9% respectively. By balancing out the canola oil as oxidative substrate, oxidative parameters like peroxide value (PV), free fatty acid (FFA) along with para-anisidine (PAV) were additionally analyzed. Cytotoxic potential investigated against the personage red blood corpuscles (RBCs) in vitro by measuring the haemolysis effect in different extracts of P. graveolens roots and range of % lysis 1.3-4.5%was explored. The outcomes from the present research work exhibited that petroleum ether and methanol extracts of P. graveolens roots exhibited enhanced anti-oxidative characteristics and lesser cytotoxic effect.