Abstract: The combination of anemia in malarial infestations ranges from nutritional deficiency to marrow suppression. An immune hemolytic anemia in Plasmodium falciparum malaria is also a part of this wide-ranging spectrum. But the co-existence of cold agglutinins in a Plasmodium falciparum malaria has only sporadically been reported in literature. We present a case of a patient with falciparum malaria who developed severe anemia and jaundice at the time of presentation. The Coombs’ test and cold agglutinin test were negative. This case underlines a rare association of cold agglutinins in Plasmodium falciparum malaria.