Abstract: Princely State of Mysore in India was under the British colonial rule during 1881 to 1947.This historical research article aims to document the role of Princely Mysore State in campaigning against the outbreak of Malaria. The methodology adopted is the historical perspective. Modus operandi adopted by the Princely Mysore state to counter the deadly epidemic is also highlighted. There has been a remarkable progress in the prevention, control and eradication and adapted vigorous measures to eradicate the disease. The article also deals with the large sums of money spent by the State, the epidemic disease regulation passed, a separate intensive health campaign formed, health camps, special officers appointed, a laboratory, separate hospitals established and various precautionary measures adopted. Infectious diseases still remain among the leading causes of death worldwide. New findings show similarities among H1 N1, Dengue and Malaria.