Abstract: Introduction: Keerom regency is the most prevalent malaria in Papua (17.7%). The control program launched since 1963 were not able to decrease the prevalence. It is necessary to find out the dominant malaria risk factors in order to enhance the malaria control program. Methods: A prospective cohort prognostic study followed 606 subjects for three months to find out the malaria dominant risk factors. Prior to finding the dominant risk factors, bivariate analysis using chi square and multivariate logistic regression were used in this study.