Abstract: Dengue is the most important mosquito-borne, arbovirus infection found worldwide. Clinical presentation varies from a flu-like illness to a potentially fatal dengue hemorrhagic fever and dengue shock syndrome. Dengue virus has been regarded as a nonneurotropic virus. However, there are reports describing neurological involvements in dengue virus infection. The neurological involvement in dengue virus infection includes encephalitis, acute disseminated encephalomyelitis, transverse myelitis, and Guillain–Barre syndrome. The neurological spectrum of dengue patients has been limited because of small number of case reports, and lack of further workup such as imaging, and neurophysiologic studies. There are only a few isolated case reports and case series documenting acute pure motor quadriparesis in dengue fever. We report acute pure motor reversible quadriparesis due to hypokalemia in a dengue patient. Physicians in the endemic area should be aware of such association of acute pure motor reversible quadriparesis with dengue fever.