Abstract: This study was conducted to assess the influence of Plasmodium falciparum parasitaemia on Platelate (children) (6-59), at Bulumkutu Comprehensive Health Centre Maiduguri, Borno State, between August to December, 2018. A total of 210 children were enrolled in the study which consisted of 88 (41.9%) patients with positive P. falciparum malaria and 122 (58.10%) negative malaria. Hematological parameters were analyzed using sysmex haematology auto-analyser (2011), while the Giemsa stained slides thick and thin blood films were prepared from the stock solution, and tested for Plasmodium falciparum malaria and count of malaria parasite density. A positive correlation was observed between the parasite density and white blood cell of (children tested positive) as index of leucocytosis (r2 = 0.831, P = 0.001) and positive correlation was observed between parasite and white cells of males females subjects respectively, where (r2 = 0.735, p = 0.001) for males and (r2 = 0.710, p = 0.001) for females.