Abstract: Medicinal plants are used in traditional medicine throughout the world. In addition to this, certain communities consider medicinal plants to be safer than drugs and able to treat more than one ailment. This study aimed to evaluate the cytotoxicity and anti-inflammatory effects of Euclea crispa (leaf), Eulea natalensis (leaf), Schkuhria pinnata (leaf), Ziziphus mucronata (leaf), Ziziphus mucronata (fruits), Lippia javanica (leaf), Vernonia oligocephala (leaf), Clerodendrum myricoides (leaf), and Erythrina lysistemon (leaf) in C2C12, and RAW 264.7 cells. Plants were extracted with 90% methanol (1 g/10 ml) and diluted in distilled water to give a final concentration of 10 mg/ml. C2C12, and RAW 264.7 cells were treated for 24 h with various concentrations of plant extracts (10 - 1000 µg/ml).