Abstract: Caroteniods, the colorful plant pigments some of which the body can turn into Vitamin A, are powerful antioxidants that help prevent some forms of cancer, heart diseases and act to enhance immune response to infections. The aim of this study is to investigate the effects of oral administration of carotenoid on the kidney of adult wistar rats. Twenty healthy wistar rats weighing between 150-210Kg were used. They were divided into four groups (A, B, C & D) of five animals each. Group A served as the control and received 0.35ml of distilled water; the experimental groups B, C & D were orally treated with 0.4ml, 0.5ml and 0.6ml of carotenoid respectively for twenty one days. Twenty four hours after the last administration, the animals were weighed, anaesthetized using chloroform inhalation method and dissected.