Abstract: Background: Intensive Care Unit (ICU) is a ward that is prone to nosocomial infections. Mechanical ventilation (MV) support is often required by 10-20% of patients admitted to the ICU, where there is always a risk of developed Ventilator-Acquired Pneumonia (VAP). Poor oral hygiene can lead to bacterial colonization of the oropharynx and aspiration of oropharyngeal secretions into the lower respiratory tract is a major factor in the occurrence of VAP. In addition, VAP is an important cause of morbidity, increased use of health resources, increased length of ICU stay and costs. Therefore, since 2003, various efforts have been made to reduce the incidence of VAP in the ICU, one of which is the use of antiseptic mouthwash which is expected to reduce the incidence of VAP. Objective: Obtain the results of chlorhexidine 0,2% mouthwash compared to povidone iodine 1% mouthwash in preventing the incidence of Early VAP in RSUP Haji Adam Malik Medan.