Abstract: Introduction: Gastrointestinal endoscopy procedures cause discomfort to patients. Administration of sedation to relieve anxiety and discomfort, improve the results of the examination, and reduce the patients memory of the event. Effective sedation can be judged by how well the drug achieves rapid onset of sedation, hemodynamic stability and fast recovery time. Ketamine maintains hemodynamic stability and sufficient depth of sedation during EGI procedures. Administering ketamine prevents bradycardia, hypotension and achieves sufficient and prolonged sedation..