Abstract: The major risk factor of cardio vascular disease is related to disturbances in lipids profile result in hyperlipidemia1 . Our present study is to evaluate antihyperlipidemic effect of ethanol extract of balanites aegyptiaca fruit (EEBAF) in Triton x-100 induce hyperlipidemic rats in animal models. The Triton X-100 solution 100 mg/kg it is used to induced hyperlipidemia by elevating serum triglyceride in animals models2. Treatment with ethanol extract of balanites aegyptiaca 200 mg and 400 mg dose significantly decreased in Tc ,TG, & LDL-c serum levels and increased in HDL-c serum levels when compared to hyperlipidemic treated rats. The redaction in HDL-c is one major factors of pathogenesis of atherosclerosis. After administration of EEBAF result increased in HDL-c levels. We could conclude that the EEBAF having good cardio -protective agent this effect due Phenolics and Flavonoids present in EEBAF extract.