Abstract: In cases of recurrent periapical abscess occurring post peri-apical surgery, platelet rich fibrin presents a viable alternative to bone grafts for osseous defects. Bone grafts may act as a nidus in cases where there is incomplete removal of granulation tissue. It is a 2nd generation platelet concentrates, which is a natural scaffold, derived from an autogenous preparation of concentrated platelets from human blood. These case reports illustrate the use of PRF in management for recurrent periapical abscess following failed periapical surgeries with bone grafts.