Abstract: Introduction: Melasma is an acquired, chronic, hyperpigmentation disorder which characterized by light-brown to bluish-gray macules and patches. Some researchers have reported an association between low serum zinc levels and various dermatological conditions including melasma. Zinc is one of the essential micronutrients known to play a role in the etiopathogenesis of melasma through its anti-inflammatory and antioxidant effects. To date, no research has been conducted to assess the relationship of serum zinc levels with the severity of melasma.