Abstract: Over 500,000 people in the United States and over 8 million people worldwide are dying every year from cancer. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Cancer is a genetic disease; thus, CRISPR is a method enables us to delete a portion of the genome. Other treatments did not serve the wanted demands; that is, it could help in tackling cancer, but with victimizations. Hence, it is time to tackle the Cancer by this genome editing tool.