Abstract: Influenza is a highly communicable viral infection capable of causing widespread epidemics and pandemics. Influenza A and B viruses are the major causative agents of human respiratory infections. Continuous surveillance of influenza virus activity and its circulating subtypes is essential to enable policymakers to make effective and appropriate decisions regarding its control. Therefore, A hospital-based observational study was conducted at the ICMR-Viral Research and Diagnostic Laboratory (VRDL), Government Medical College, Akola to determine the pattern of influenza virus activity in relation to various meteorological and clinical parameters.