Abstract: Despite the non-contraceptive benefits hormonal contraceptives offer to women with haemoglobin SS, the utilization of hormonal contraceptives is on the decrease. The study sought to assess the knowledge, attitudes and barriers to the use of hormonal contraceptives among women with SCD in the Kumasi metropolis. The study used questionnaires to collect primary data from 378 women with haemoglobin SS within their reproductive ages. The results of the study showed that knowledge was not significantly associated with the use of contraceptives among women with SCD.