IJSRP, Volume 7, Issue 12, December 2017 Edition [ISSN 2250-3153]
B.Rama, C.Varun Reddy, A.Sneha, D.Niharika, G.Sravani, S.Divya Laxmi
The recent developments of Floating drug delivery system which includes the gastric physiology and different variables in formulation affects gastric retention in turn improves the bioavailability of drugs especially which have a narrow absorption window. The aim of the work was to develop and evaluate gastro retentive floating drug delivery of Metformin hydrochloride as a model drug to increase the gastric residence time. The tablets of Metformin hydrochloride were prepared with hydrophilic and hydrophobic polymers like HPMC K-15, Ethylcellulose with and without disintegrant carboxy methyl cellulose. Developed formulations were evaluated for the pre compression parameters, post compression parameters, FLT, and in vitro dissolution study. From the results it was concluded the formulation F6 showed comparatively good release which complies with the dissolution requirements.