Abstract: AIMS AND OBJECTIVE: To observe the treatment of hepatitis C and to compare the oral drug therapy with interferon . Methods: An cross sectional study was conducted in outpatient departments of different hospitals of Pakistan including( Jinnah hospital Lahore, Services hospital Lahore, Sheikh zayed hospital Lahore, Mayo hospital and Victoria Hospital Bahawalpur). Data of 100 patients within 20 years-70years of age, diagnosed with hepatitis C, was collected using convenient sampling technique during face to face interviews with patients .Then data was compiled, analyzed and presented in tabular form.