Abstract: The present study was designed to investigate n-type perovskite oxide based superlattices as a potential materials system for thermoelectric power generation. The model based on the phonon Boltzmann transport equations with diffuse mismatch interface conditions has been used to calculate the lattice thermal conductivity of SrTiO3/TiO2 nanostructures. Result shows that in the superlattice nanowire structure the interface scattering cause the reduction in phonon thermal conductivity. . It was also found that nanowire boundary scattering provides significant resistance to phonon transport. The reduced thermal conductivity of superlattice nanowire was found to be 1.156 W/mK for dw=0.44 nm and L=5 nm. As the diameter increases, the nanowire boundary scattering decreases, which leads to increase nanowire thermal conductivity. The obtained results suggest that, by optimizing the periodic length and the wire cross-sectional width, SrTiO3/anatase TiO2 superlattice nanowire can be a very good candidate as materials for high performance, efficient thermoelectric material. However the reduction in thermal conductivity is more effective due to the reduction in diameter of nanowire as compared to reduction in periodic length of the nanowire.