Abstract: The aim of the study was to assess the antibacterial effect of Ficus sycomorus extracts and their synergistic antibiotics against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The extract of medicinal plants were prepared using Soxhlet apparatus for alcoholic extract, and water reflux for aqueous extracts. The results of this study showed that ethanolic extracts of Ficus were showed against E. coli, S. aureus and P. aeruginosa, While Aquatic extract showed synergistic effect with some antibiotics better than organic solvent. The results of this study showed that there is a decrease in MIC in case of methanolic extract of F. sycomorus extracts against selected bacteria.