Abstract: Fluoride occurs in the environment in water, soil, air, food, and vegetation significantly increased body burden, fluoride was discovered by karl schele in 1771, recognize as halogen in 1825, it was the 13 most abundant elements in earth crust. The range of species in animal experiments that reported adverse effects. Fluoride is the ionic form of the most electronegative elements fluorine, which is widely distributed in igneous and sedimentary rocks; earth’s crust and oceans. Water pollution has become world-wide phenomenon. Both deficiency and excess of minerals and trace elements in water can have deleterious consequences on biological system. The major ecological problem are the pollutants from industries, pesticides, herbicides, fertilizers and chemicals.