Abstract: The aim of the study was to investigate the personal factors that affect the uptake of voluntary medical male circumcision among the sexually active populations in Busia County, Kenya. The study adopted a mixed methods research design. The researcher targeted males enrolled in three government funded institutions (Bumbe Technical Institute, Nangina Youth Polytechnic and Namasali Youth Polytechnic) based in Funyula Sub-County which was chosen since the predominant community living in this area-the Samia, don’t practice male circumcision. Simple random sampling technique was applied to select males who were issued with questionnaires and included in the final research sample. A total of 249 males participated in the research. The researcher was able to establish hat personal factors especially beliefs and attitudes of the Samia community affected the uptake of voluntary medical male circumcision which has been rolled out by government and non-governmental institutions with the objective of reducing the HIV/AIDs infections in the country.