IJSRP, Volume 7, Issue 11, November 2017 Edition [ISSN 2250-3153]
Modugula S Naga Swetha, Srinivasa S.V, Abhishek Kumar Verma, Prabhakar K
Diabetes mellitus is a severe metabolic disease which can effect multiple organs in the body. It is a complex disorder and several factors related to it, either the disease itself or its treatment, long-term complications and comorbidities can affect the brain1. Type 2 diabetes has been consistently associated with increased risk of accelerated cognitive decline2 and an higher incidence of dementia,3,4 particularly in older individuals. Patients with Type 2 Diabetes mellitus are almost two times more likely to experience cognitive decline and dementia compared to those with normal glucose tolerance (NGT).4 Studies have suggested that T2DM effects cognitive domains like verbal memory (verbal fluency, immediate and delayed verbal recall), attention and processing speed, psychomotor ability, and executive functions.5,6. Diabetes has also been observed to be related with cognitive decrements such as worsening of abstract reasoning7, complex motor functioning and working memory7.