Abstract: The use of biomass indoor Honai (traditional house) in Wamena have been conducted for several decades and become a traditional habit of Honai occupants. Since air temperature at night in Wamena Regency is cold the inhabitans burn the Kasuari woods to warm their body. As a result, they continuously inhale the Sulfur Dioxide (SO2) and Nitrogen Dioxide (NO2) and some contaminated air in Honai room daily which may lead to varies illnesses. This study aimed to investigate the SO2 and NO2 contaminated Honai indoor air, record the air contaminated inhalation rate and lung vital capacity among the honai occupants at five villages in Wamena regency. Samples were collected from 15 Honai before and after the honai modification by recording the SO2 and NO2 levels.