Abstract: Infertility is a global issue affecting many couples. Oxidative stress (OS) damages sperm through lipid peroxidation and protein oxidation, reducing seminal quality. The imbalance between antioxidants and reactive oxygen species (ROS) due to various factors like lifestyle, diet, genetics, and OS contributes to male infertility. High ROS levels damage sperm parameters, including DNA and protein structures. Addressing OS through lifestyle changes and antioxidant therapy can help manage male infertility. However, identifying the exact causes of OS-induced infertility remains challenging. This review explores the role of oxidative stress in male infertility and current management strategies.