Abstract: The Hospital Information System (HIS) is a collection of several parts of the way that relate to one another and form a unified whole that is in a hospital. The ongoing Hospital Information System at RSGM UMY is needed in its work activities. Therefore, it is necessary to have a quality measurement of the RSGM information system. This research uses a quantitative research method. The study population was dental students who used HIS at RSGM UMY, which in this study the subjects were about 200 people. Data collected using questionnaires and analyzed using descriptive analysis with percentage analysis techniques.