International Journal of Scientific and Research Publications

IJSRP, Volume 11, Issue 10, October 2021 Edition [ISSN 2250-3153]


Hepatorenal Functions Following Prolonged Oral Administration of Caffeine on Male Wistar Rats
      Ekamadu Hope Ukame, Ojeka Sunday Ogbu and Zabbey Victor Zigabelbari
Abstract: Caffeine is the most widely used natural stimulant, found in beverages, medicine and some popular masticatories. The aim of this study was to investigate the effects of prolonged oral administration of caffeine on hepatorenal functions of male Wistar rats. In this study 32 Wistar rats (120g-240g) were used. The animals were divided into four groups of 8 rats each with group 1 as control given only feed and water. Group two were given 2mg/kg caffeine, group 3 given 4mg/kg caffeine and group 4 given 6mg/kg caffeine orally for 28 days. The result showed significant decrease in body weight. There was also a statistically significant increase in the concentrations of urea, creatinine, uric acid, bicarbonate and chloride in groups 3 and 4 and a statistically significant decrease in the concentrations of potassium and sodium in groups 3 and 4.

Reference this Research Paper (copy & paste below code):

Ekamadu Hope Ukame, Ojeka Sunday Ogbu and Zabbey Victor Zigabelbari (2021); Hepatorenal Functions Following Prolonged Oral Administration of Caffeine on Male Wistar Rats; International Journal of Scientific and Research Publications (IJSRP) 11(10) (ISSN: 2250-3153), DOI: http://dx.doi.org/10.29322/IJSRP.11.10.2021.p11839
©️ Copyright 2011-2022 IJSRP - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.