Abstract: The emergence of recent outbreaks and the current pandemic have had increasing demands for past and present patient medical information, as preparedness and response strategies, create new data sharing and exchange demands on health information systems (HIS). A review of interoperability technique and human mobility mapping was critically examined and key design requirements during HIS implementations as parameters to improve the current health systems across mobility corridors. This paper also presents a mobility mapping network methodology and to support health authorities for preparedness and response especially areas in the health sectors that require improvement for any infectious diseases and future outbreaks or pandemic transmission. To realize the universal health coverage (UHC), we present some key parameters matrix; level of care, national standards and guidelines, health promotion, health education, safe blood transfusion, mobile clinics and field hospitals, infection control in healthcare settings, and patient safety, and healthcare waste management.