Abstract: Globally diabetes is a one of the major health challenges disease. This disease direct impact the socio economical level in person and country. Diabetes Mellitus is caused by lack of insulin activity. In type 2 diabetes there is resistance to the action of relative insulin it cause insulin deficiency. Ancient Siddha text Sarabenthira Vaithiya Muraigal has mentioned that Neerizhivu and their management under the Neerizhivu Sigitchai.’’Neerizhivu can be correlated with the Diabetic mellitus. Nelliyathi kasayam is mentioned for the treatment of Neerizhivu (diabetic). Nelliyathi kasayam is a poly herbal formula which include the following herbs such as Phyllanthus emblica, Strychnos potatorum, Tereminalia bellirica, Cissampelos pareira, Cyperus rotundus.