Abstract: The ultimate purpose of any constitution in either granting or denying constitutional secession right should be maintaining the unity and territorial integrity of the state. Granting constitutional secession right will have both benefit as well as a cost. To reap the benefit, constitutional secession rights should be designed wisely and skillfully in a manner they can prevent secession and maintain the unity and integrity of the state. The Federal Democratic Republic of Ethiopian constitution is among very few constitutions in the world that included secession right in their constitution. This article vehemently claims that carefully designed secession right in constitution can help to effectively prevent secession and disintegration of a multi-national state. However, the secession right as it appears in the current Federal Democratic Republic of Ethiopian constitution cannot prevent secession, if the right is going to be operationalized. The clause in the constitution lacks the capacity of making secession difficult. Similarly, repealing the secession right out of the Federal Democratic Republic of Ethiopian constitution without bloodshed seems very difficult. Hence, the only option is revisiting and amending the clause and the procedures of secession in which it can wisely and effectively sabotage and prevent secession and disintegration while maintaining the unity and territorial integrity of the Ethiopian state.