Abstract: The purpose of the study was to analyze the determinants of effective fraud management in domestic tier one commercial banks in Trans Nzoia County. The analysis was focused on the domestic tier one commercial banks in the County as the population of the study. The study was guided by the following objectives; to analyze the effect of the independence of the internal audit personnel, the competence of the internal audit personnel, the presence of the internal audit charter and the management support as determinants of effective fraud management in the d0mestic tier one commercial banks.