Abstract: Background: Myocardial infarction (MI) is one of the major causes of morbidity and mortality in developed countries. Currently, it becomes increasingly more common in developing countries as Morocco. The Alu family of short interspersed elements was widely used as a highly informative tool for studying genetic structure of human populations because of their unique mutational mechanism. In this study, we aim to investigate the association between four Alu polymorphisms located at the ACE, FXIII-B, PLAT TPA-25 and APOA1 genes and the risk of MI in Moroccan population.