International Journal of Scientific and Research Publications

IJSRP, Volume 4, Issue 10, October 2014 Edition [ISSN 2250-3153]


Association between polymorphism in APOC3, and Metabolic Syndrome in the Moroccan Population
      Maria Ajjemami, Houria Rhaissi, Houda Benrahma, Hicham Charoute, Errouagui Abdeltif, Fouzia Lakbakbi el yaagoubi, Mostafa Kandil, Abdelhamid Barakat, Hassan Rouba
Abstract: Metabolic syndrome (MS) is regarded as a real public health problem its prevalence rises each year as well as its morbidity. It is a multi factorial disease and besides environmental factors and genetic factors also contribute to the pathogenesis of MS. In several studies the SstI (3238C> G) polymorphism of APOC3 gene is associated with increased plasma concentrations of triglyceride (TG) and hypertriglyceridemia. The aim of the present study was to determine the association between polymorphism 3238C> G in APOC3, and Metabolic Syndrome in the Moroccan Population. Statistical analysis has revealed an association of polymorphism APOC3 3238C>G susceptibility with the metabolic syndrome in two models, codominant 1 [OR = 4.21 [1.66-10.68], p = 0.0008] and dominant [OR = 3.83 [1.59-9.19] p = 0.0010]. The variant APOC3 3238G were associated with elevated TG levels (P = 0.0146) and LDL-C (p = 0.0068) compared to patients with MS and controls non-carriers of this variant.

Reference this Research Paper (copy & paste below code):

Maria Ajjemami, Houria Rhaissi, Houda Benrahma, Hicham Charoute, Errouagui Abdeltif, Fouzia Lakbakbi el yaagoubi, Mostafa Kandil, Abdelhamid Barakat, Hassan Rouba (2018); Association between polymorphism in APOC3, and Metabolic Syndrome in the Moroccan Population; Int J Sci Res Publ 4(10) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-1014.php?rp=P343231
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