Abstract: Metabolic syndrome (MS) is regarded as a real public health problem its prevalence rises each year as well as its morbidity. It is a multi factorial disease and besides environmental factors and genetic factors also contribute to the pathogenesis of MS. In several studies the SstI (3238C> G) polymorphism of APOC3 gene is associated with increased plasma concentrations of triglyceride (TG) and hypertriglyceridemia. The aim of the present study was to determine the association between polymorphism 3238C> G in APOC3, and Metabolic Syndrome in the Moroccan Population. Statistical analysis has revealed an association of polymorphism APOC3 3238C>G susceptibility with the metabolic syndrome in two models, codominant 1 [OR = 4.21 [1.66-10.68], p = 0.0008] and dominant [OR = 3.83 [1.59-9.19] p = 0.0010]. The variant APOC3 3238G were associated with elevated TG levels (P = 0.0146) and LDL-C (p = 0.0068) compared to patients with MS and controls non-carriers of this variant.