Abstract: Pre-exposure Prophylaxis (PrEP) is effective in prevention of Human Immunodeficiency Virus (HIV) infections among populations at a substantial risk. World Health Organization recommends use of PrEP for prevention of HIV, however, risk of sexually transmitted Infections (STIs) raises concern. While STIs screening is continually done at PrEP refill visits and cases treated, increased risk of STIs may reduce the prevention benefits of PrEP while increasing STI rates with ultimate impact on economic and health burdens.