Abstract: Senna occidentalis leaves were collected at Maiduguri Metropolitan Council (MMC) of Borno State, Nigeria and extracted in water by simple maceration method. The aqueous extract was tested for its analgesic activity in Wistar albino rats by tail flick method, where the result showed significant (P<0.01) increase in reaction time from 6.60±0.20 to 8.00±0.32 compared with the control (5.00±0.00) for the extract graded doses of 200 to 600 mg/kg, at 30 minutes post treatment; 7.20±0.37 to 8.60±0.24 compared with the control (4.60±0.24) for the same graded doses of the extract, 60 minutes post treatment; 5.60±0.24 to 7.60±0.24 compared with the control (4.60±0.24) for the same graded doses of the extract, 90 minutes post treatment; and 5.20±0.20 to 6.40±0.24compared with the control (4.60±0.24) for the same graded doses of the extract, 120 minutes.