Abstract: Climate change-related risks, such as health, resources disparities, vulnerability, and food insecurity are increasing in Benin, West Africa (WA). Morbidity and mortality based of vectors borne diseases (malaria, meningitis, dengue, cholera, etc.), air pollution-related respiratory diseases, and climate extremes events (floods, droughts, etc.) and heatwaves are most likely risks. Several studies have been carried out on climate change in Benin. But none showed methodologically consistent and detailed and giving any certitude on the analysis of temporal-spatial trends and the future climate of the country. As a result, the climate remains uncertain and no studies have been carried out to assess the impact of climate change on health over Benin. While, the risks of the appearance of vector-borne diseases (VBD) that are sensitive to climatic variations and changes, such as malaria, meningitis, dengue fever, cholera, etc. remain and magnifying day to day.