Abstract: There are many factors which affect nurse perfomance level. However, few studies have addressed the influence of work scheduling on nurses performance while providing patient care. This study aimed at identifying the influence of work scheduling on performance of nurses in regional hospitals in Tanzania. The study adopted descriptive survey research design using both quantitative and qualitative approaches. A target population of 410 from which a sample size of 387 was randomly selected through stratified random sampling method Pearson correlation, independent t- test, one-way Analysis of Variance (ANOVA), and linear regression method were employed to analyze data.