Abstract: This study was designed to find the correlation between changes in lipid profile and liver marker enzymes in HIV-infected and AIDS patients. The study population consisted of 150 subjects, age and sex-matched and divided into three groups [control subjects (n=50), HIV infected (n=50) and AIDS patients (n=50)]. Serum levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were found to be decreased significantly in HIV/AIDS patients when compared with normal counterparts. On the other hand, the levels of triglyceride (TG) and very low-density lipoprotein cholesterol (VLDL-C) were markedly elevated in HIV/AIDS patients compared to normal subjects. The activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) observed in HIV/AIDS patients were significantly higher than in the control group. Further, the above mentioned biochemical variables were found to be affected more significantly in AIDS patients when compared with HIV infected subjects. Hence, it may be concluded that lipid profile and liver enzymes can be a good index of disease progression in HIV infection and AIDS patients.