Abstract: The Students’ Variables as Predictor of Secondary School Students’ Performance in Science in Ikere Local Government Area of Ekiti State, Nigeria was investigated in this study. The study adopted a survey research design of the ex-post facto type. The sample comprised 125 senior secondary school II science students drawn from the five secondary schools in Ikere Local Government Area of Ekiti state. The instruments used for the study was questionnaire and past academic performance in three science subjects (Biology, Chemistry and Physics) of the students involved in the study. Two research hypotheses were generated and analysed in the study using Pearson’s Moment Correlation and Multiple regression statistical analysis. Among others, the study revealed that: students‘ variables (study habit, attitude to and interest of students in Science subjects ) are better predictors of students’ performance in science subjects, while student gender has no influence on students academic performance . The results also revealed the individual contribution of students’ variables to students performance in term of beta weight 0.231 (23.1%), 0.202 (20.26%), 0.181 (0.18.1%) and 0.101 10.1%) for students attitude to Science, study habit, students interest and gender of the students respectively. Conclusion and recommendations were also made in this paper.