Abstract: The Ministry of Health in Kenya rolled out on HMIS policy in the year 2010. The policy directed that healthcare organizations in Kenya should shift from paper-based health information system to electronic integrated health information systems. However research indicates that HMIS in Kenya are to a large extent still paper based 8 years later. This paper addresses the impact of technical factor on the integration of HMIS. Moreover it also tests whether human infrastructure, IT infrastructure and systems interoperability have an impact on integration of HMIS. Data from a sample of 243 HMIS users were collected and analyzed. Results indicate that technical factor is positively related to integration of HMIS. Whereas a significant relationship was found between human infrastructure, IT infrastructure and systems interoperability. The critical link to integration of HMIS was found to be in systems interoperability, meaning that the more the Health Management Information Systems become interoperable the more likely integration of HMIS is likely to be attained.