Abstract: Persons with disabilities make up an estimated 15 per cent of the world population, over one billion–80% of who live in developing countries (WHO report). They frequently experience discrimination and face barriers to participation in all aspects of society, in accessing education, employment, health care, social recognition and transportation. Some persons with disabilities face multiple barriers to their participation, due to discrimination on the basis of other grounds, including race, colour, sex, language, religion, political or other opinion, national, ethnic, indigenous or social origin, property, birth and age. As a result, persons with disabilities are at a high risk of poverty, which in itself increases the likelihood of having a disability. Given that persons with disabilities represent a significant portion of the world population, the world’s largest minority and are more likely to live in poverty than their non-disabled peers, their inclusion in all development activities is essential, if internationally agreed development goals, including the Millennium Development Goals (MDGs) are to be achieved in an equitable manner. The Convention on the Rights of Persons with Disabilities (CRPD) and its Optional Protocol (OP) 2 provide the normative framework for Member States to address the rights of persons with disabilities and to ensure that they are included in all development efforts. Differently-abled entrepreneurs, as a new and emerging group of entrepreneurs and a new breed of entrepreneurs, and act as a catalytic force for the socio-economic development of socially disadvantaged.